NAD⁺: The Cornerstone of Cellular Energy and Longevity Research

At Academic Chem Lab (ACL), we are dedicated to advancing research by providing high-quality compounds that play a central role in cellular biology. One of the most important and widely studied molecules today is Nicotinamide Adenine Dinucleotide (NAD⁺)—a coenzyme essential for energy production, DNA repair, and healthy cellular function.

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What is NAD⁺?

NAD⁺ is a pyridine nucleotide that acts as a coenzyme in thousands of redox reactions throughout the body. It is present in all living cells and is critical to life-sustaining metabolic processes.

• Chemical Name: β-Nicotinamide Adenine Dinucleotide, Oxidized Form

• CAS Number: 53-84-9

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂

• Molecular Weight: 663.43 g/mol

• Appearance: White to off-white powder or crystalline solid (depending on preparation form)

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The Biological Importance of NAD⁺

NAD⁺ is indispensable for multiple cellular pathways:

1. Energy Metabolism

   • Central to the Krebs cycle and electron transport chain, NAD⁺ enables the production of ATP, the body’s main energy currency.

2. DNA Repair

   • Serves as a substrate for PARPs (Poly ADP-Ribose Polymerases), which repair damaged DNA and maintain genomic stability.

3. Sirtuin Activation

   • Required for the activation of sirtuins, a group of enzymes linked to stress resistance, healthy aging, and metabolic regulation.

4. Oxidative Balance

   • NAD⁺ cycles with its reduced form (NADH), maintaining redox balance and supporting cellular detoxification.

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Research Benefits & Areas of Interest

NAD⁺ is strictly for research-use only, but it is currently being studied in diverse areas, including:

• Healthy Aging & Longevity – Declines in NAD⁺ levels are associated with aging; replenishment is being studied as a way to support long-term cellular health.

• Neuroprotection – Research investigates NAD⁺ in relation to brain health, memory, and neurodegenerative conditions.

• Metabolic Health – Explored for roles in mitochondrial biogenesis, insulin sensitivity, and fat metabolism.

• Exercise & Recovery – Investigated for potential effects on energy utilization, endurance, and recovery time.

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Current Standing in Research

As of 2025, NAD⁺ research has grown exponentially. Declining NAD⁺ levels are considered a hallmark of aging, and global studies are investigating strategies to restore its availability—either through direct NAD⁺ supplementation or via precursors like NMN (β-Nicotinamide Mononucleotide, CAS 1094-61-7, MW 334.22 g/mol) and NR (Nicotinamide Riboside, CAS 1341-23-7, MW 255.25 g/mol).

At Academic Chem Lab, every batch of NAD⁺ will be tested for purity, consistency, and molecular integrity to support researchers in generating accurate, reproducible data.

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Coming Soon: NAD⁺ at ACL

Because so many researchers requested it, we are excited to announce that NAD⁺ will be available soon at Academic Chem Lab. We’ve listened to your feedback and are in the final stages of preparing this compound for research release.

Stay tuned for launch details, availability dates, and early-access notifications through our email updates and the ACL Pep & BioNews community.

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Key Stats Recap

• Compound: NAD⁺ (β-Nicotinamide Adenine Dinucleotide, oxidized form)

• CAS Number: 53-84-9

• Formula: C₂₁H₂₇N₇O₁₄P₂

• Molecular Weight: 663.43 g/mol

• Status: Research-use only. Not for human consumption.

• Availability: Coming soon to Academic Chem Lab by popular request.

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Final Thoughts

NAD⁺ is one of the most essential biomolecules for life. Its involvement in energy production, DNA repair, and longevity research makes it a powerful focus of modern science. At Academic Chem Lab (ACL), we’re proud to deliver high-quality research-grade compounds—now including NAD⁺, available soon thanks to the requests of our dedicated research community.